In recent decades, the concept of regional development has become one of the fundamental axes in spatial planning and policy studies. The main goal of regional development is to achieve a balance in the enjoyment of economic, social, and environmental opportunities between different regions and to sustainably improve the living standards of citizens. The equitable distribution of health services is a fundamental indicator of sustainable regional development, while disparities in access—especially in deprived areas—can lead to broad social and economic consequences. Accordingly, this study aims to analyze the spatial inequality of regional health development in Sistan and Baluchistan Province using Multi-Criteria Decision-Making (MCDM) models and Geographic Information Systems (GIS). Statistical data were obtained from the Iranian Statistical Center (2021) and included 86 health indicators categorized into four main dimensions: health human resources, medical infrastructure, specialized and supportive health centers, and primary healthcare networks. After normalization and inverse adjustment of negative indicators, the Simple Weight Calculation (SIWEC) method was applied to assign weights, followed by the MABAC model to rank the counties. The weighted results were spatially analyzed in GIS using Kriging interpolation to visualize the spatial distribution of health inequalities. The findings revealed significant disparities across the Sistan and Baluchistan province, with Zabol, Zahedan, Iranshahr and Fannuj showing the highest levels of health development, while Lashar, Golshan, and Zarabad ranked lowest. Overall, the spatial pattern indicates a strong concentration of services in the northern regions and deprivation in the south, emphasizing the need for equity-oriented health policies and decentralized service delivery.